4n9u
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n9u RCSB], [http://www.ebi.ac.uk/pdbsum/4n9u PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n9u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n9u RCSB], [http://www.ebi.ac.uk/pdbsum/4n9u PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Barnett, B L | + | [[Category: Barnett, B L]] |
| - | [[Category: Dunford, J E | + | [[Category: Dunford, J E]] |
| - | [[Category: Ebetino, F H | + | [[Category: Ebetino, F H]] |
| - | [[Category: Evdokimov, A | + | [[Category: Evdokimov, A]] |
| - | [[Category: Kavanagh, K L | + | [[Category: Kavanagh, K L]] |
| - | [[Category: Kwaasi, A A | + | [[Category: Kwaasi, A A]] |
| - | [[Category: Muniz, J R.C | + | [[Category: Muniz, J R.C]] |
| - | [[Category: Oppermann, U | + | [[Category: Oppermann, U]] |
| - | [[Category: Pilka, E | + | [[Category: Pilka, E]] |
| - | [[Category: Russell, R G.G | + | [[Category: Russell, R G.G]] |
| - | [[Category: Tsoumpra, M K | + | [[Category: Tsoumpra, M K]] |
| - | [[Category: Walter, R L | + | [[Category: Walter, R L]] |
[[Category: Alpha-helical prenyltransferase fold]] | [[Category: Alpha-helical prenyltransferase fold]] | ||
[[Category: Dimethylallyl pyrophosphate]] | [[Category: Dimethylallyl pyrophosphate]] | ||
Revision as of 18:30, 25 December 2014
The role of lysine 200 in the human farnesyl pyrophosphate synthase catalytic mechanism and the mode of inhibition by the nitrogen-containing bisphosphonates
| |||||||||||
Categories: Barnett, B L | Dunford, J E | Ebetino, F H | Evdokimov, A | Kavanagh, K L | Kwaasi, A A | Muniz, J R.C | Oppermann, U | Pilka, E | Russell, R G.G | Tsoumpra, M K | Walter, R L | Alpha-helical prenyltransferase fold | Dimethylallyl pyrophosphate | Isopentenyl pyrophosphate | Isoprene biosynthesis | Lipid synthesis | Steroid biosynthesis | Transferase
