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4byf
From Proteopedia
(Difference between revisions)
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<StructureSection load='4byf' size='340' side='right' caption='[[4byf]], [[Resolution|resolution]] 2.74Å' scene=''> | <StructureSection load='4byf' size='340' side='right' caption='[[4byf]], [[Resolution|resolution]] 2.74Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4byf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BYF OCA]. <br> | + | <table><tr><td colspan='2'>[[4byf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BYF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4BYF FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AOV:ADP+ORTHOVANADATE'>AOV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AOV:ADP+ORTHOVANADATE'>AOV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Myosin_ATPase Myosin ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.1 3.6.4.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4byf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4byf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4byf RCSB], [http://www.ebi.ac.uk/pdbsum/4byf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4byf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4byf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4byf RCSB], [http://www.ebi.ac.uk/pdbsum/4byf PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MYO1C_HUMAN MYO1C_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity). Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Crystal Structure of Human Myosin 1c - The Motor in GLUT4 Exocytosis: Implications for Ca-Regulation and 14-3-3 Binding.,Stefan Munnich MH, Manstein DJ J Mol Biol. 2014 Mar 14. pii: S0022-2836(14)00128-4. doi:, 10.1016/j.jmb.2014.03.004. PMID:24636949<ref>PMID:24636949</ref> | Crystal Structure of Human Myosin 1c - The Motor in GLUT4 Exocytosis: Implications for Ca-Regulation and 14-3-3 Binding.,Stefan Munnich MH, Manstein DJ J Mol Biol. 2014 Mar 14. pii: S0022-2836(14)00128-4. doi:, 10.1016/j.jmb.2014.03.004. PMID:24636949<ref>PMID:24636949</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Myosin|Myosin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Human]] | [[Category: Human]] | ||
[[Category: Myosin ATPase]] | [[Category: Myosin ATPase]] | ||
| - | [[Category: Manstein, D J | + | [[Category: Manstein, D J]] |
| - | [[Category: Munnich, S | + | [[Category: Munnich, S]] |
| - | [[Category: Pathan-Chhatbar, S | + | [[Category: Pathan-Chhatbar, S]] |
| - | [[Category: Taft, M H | + | [[Category: Taft, M H]] |
[[Category: Atpase]] | [[Category: Atpase]] | ||
[[Category: Glut4 exocytosis]] | [[Category: Glut4 exocytosis]] | ||
Revision as of 18:37, 25 December 2014
Crystal structure of human Myosin 1c in complex with calmodulin in the pre-power stroke state
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Categories: Human | Myosin ATPase | Manstein, D J | Munnich, S | Pathan-Chhatbar, S | Taft, M H | Atpase | Glut4 exocytosis | Hydrolase | Motor protein | Myo1c
