4li1
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4li1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4li1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4li1 RCSB], [http://www.ebi.ac.uk/pdbsum/4li1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4li1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4li1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4li1 RCSB], [http://www.ebi.ac.uk/pdbsum/4li1 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LGR4_XENTR LGR4_XENTR]] Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 18:38, 25 December 2014
Crystal Structures of Lgr4 and its complex with R-spondin1
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Categories: Rajashankar, K | Robev, D | Xu, Y | Hormone receptor | Lrr
