4l58
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l58 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l58 RCSB], [http://www.ebi.ac.uk/pdbsum/4l58 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l58 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4l58 RCSB], [http://www.ebi.ac.uk/pdbsum/4l58 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MLL5_HUMAN MLL5_HUMAN]] Histone methyltransferase that specifically mono- and dimethylates 'Lys-4' of histone H3 (H3K4me1 and H3K4me2). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Plays an essential role in retinoic-acid-induced granulopoiesis by acting as a coactivator of RAR-alpha (RARA) in target gene promoters. Also acts as an important cell cycle regulator, participating in cell cycle regulatory network machinery at multiple cell cycle stages. Required to suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. Overexpression inhibits cell cycle progression, while knockdown induces cell cycle arrest at both the G1 and G2/M phases.<ref>PMID:14718661</ref> <ref>PMID:18573682</ref> <ref>PMID:19377461</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 18:38, 25 December 2014
Crystal structure of the MLL5 PHD finger in complex with H3K4me3
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