2pk2
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2pk2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PK2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2pk2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Equine_infectious_anemia_virus Equine infectious anemia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2PK2 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pkw|1pkw]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1pkw|1pkw]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pk2 RCSB], [http://www.ebi.ac.uk/pdbsum/2pk2 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2pk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2pk2 RCSB], [http://www.ebi.ac.uk/pdbsum/2pk2 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CCNT1_HUMAN CCNT1_HUMAN]] Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
| - | *[[Cyclin|Cyclin]] | ||
*[[Tat protein|Tat protein]] | *[[Tat protein|Tat protein]] | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Equine infectious anemia virus]] | [[Category: Equine infectious anemia virus]] | ||
| - | [[Category: Anand, K | + | [[Category: Anand, K]] |
| - | [[Category: Fujinaga, K | + | [[Category: Fujinaga, K]] |
| - | [[Category: Geyer, M | + | [[Category: Geyer, M]] |
| - | [[Category: Scheffzek, K | + | [[Category: Scheffzek, K]] |
| - | [[Category: Schulte, A | + | [[Category: Schulte, A]] |
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Cyclin t1]] | [[Category: Cyclin t1]] | ||
Revision as of 18:44, 25 December 2014
Cyclin box structure of the P-TEFb subunit Cyclin T1 derived from a fusion complex with EIAV Tat
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