1r2d
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1r2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R2D FirstGlance]. <br> | <table><tr><td colspan='2'>[[1r2d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1R2D FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1maz|1maz]], [[1r2e|1r2e]], [[1r2g|1r2g]], [[1r2h|1r2h]], [[1r2i|1r2i]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1maz|1maz]], [[1r2e|1r2e]], [[1r2g|1r2g]], [[1r2h|1r2h]], [[1r2i|1r2i]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL-XL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BCL-XL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r2d RCSB], [http://www.ebi.ac.uk/pdbsum/1r2d PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1r2d RCSB], [http://www.ebi.ac.uk/pdbsum/1r2d PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2CL1_HUMAN B2CL1_HUMAN]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> Isoform Bcl-X(S) promotes apoptosis.<ref>PMID:19917720</ref> <ref>PMID:21840391</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Giedt, C D | + | [[Category: Giedt, C D]] |
| - | [[Category: Hockenbery, D M | + | [[Category: Hockenbery, D M]] |
| - | [[Category: Kim, K M | + | [[Category: Kim, K M]] |
| - | [[Category: Manion, M K | + | [[Category: Manion, M K]] |
| - | [[Category: Neill, J W.O | + | [[Category: Neill, J W.O]] |
| - | [[Category: Zhang, K Y | + | [[Category: Zhang, K Y]] |
[[Category: Alpha-helical]] | [[Category: Alpha-helical]] | ||
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Monomeric]] | [[Category: Monomeric]] | ||
Revision as of 18:45, 25 December 2014
Structure of Human Bcl-XL at 1.95 Angstroms
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