4aw5
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4aw5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AW5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4aw5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AW5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AW5 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30K:(3Z)-5-[(1-ETHYLPIPERIDIN-4-YL)AMINO]-3-[(5-METHOXY-1H-BENZIMIDAZOL-2-YL)(PHENYL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE'>30K</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=30K:(3Z)-5-[(1-ETHYLPIPERIDIN-4-YL)AMINO]-3-[(5-METHOXY-1H-BENZIMIDAZOL-2-YL)(PHENYL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE'>30K</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bba|2bba]], [[2vwu|2vwu]], [[2vwv|2vwv]], [[2vww|2vww]], [[2vwx|2vwx]], [[2vwy|2vwy]], [[2vwz|2vwz]], [[2vx0|2vx0]], [[2vx1|2vx1]], [[2x9f|2x9f]], [[2xvd|2xvd]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bba|2bba]], [[2vwu|2vwu]], [[2vwv|2vwv]], [[2vww|2vww]], [[2vwx|2vwx]], [[2vwy|2vwy]], [[2vwz|2vwz]], [[2vx0|2vx0]], [[2vx1|2vx1]], [[2x9f|2x9f]], [[2xvd|2xvd]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aw5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aw5 RCSB], [http://www.ebi.ac.uk/pdbsum/4aw5 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aw5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aw5 RCSB], [http://www.ebi.ac.uk/pdbsum/4aw5 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EPHB4_HUMAN EPHB4_HUMAN]] Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.<ref>PMID:12734395</ref> <ref>PMID:16424904</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
| - | [[Category: Stout, T J | + | [[Category: Stout, T J]] |
| - | [[Category: Till, J H | + | [[Category: Till, J H]] |
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 18:52, 25 December 2014
Complex of the EphB4 kinase domain with an oxindole inhibitor
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