2o90
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2o90]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O90 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2o90]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2O90 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NEU:L-NEOPTERIN'>NEU</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NEU:L-NEOPTERIN'>NEU</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nm2|2nm2]], [[2nm3|2nm3]], [[1dhn|1dhn]], [[2dhn|2dhn]], [[2oak|2oak]], [[2o9m|2o9m]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nm2|2nm2]], [[2nm3|2nm3]], [[1dhn|1dhn]], [[2dhn|2dhn]], [[2oak|2oak]], [[2o9m|2o9m]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">folB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroneopterin_aldolase Dihydroneopterin aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.25 4.1.2.25] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroneopterin_aldolase Dihydroneopterin aldolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.25 4.1.2.25] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o90 RCSB], [http://www.ebi.ac.uk/pdbsum/2o90 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2o90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o90 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2o90 RCSB], [http://www.ebi.ac.uk/pdbsum/2o90 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FOLB_ECOLI FOLB_ECOLI]] Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin at appreciable velocity. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Dihydroneopterin aldolase]] | [[Category: Dihydroneopterin aldolase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Blaszczyk, J | + | [[Category: Blaszczyk, J]] |
| - | [[Category: Ji, X | + | [[Category: Ji, X]] |
| - | [[Category: Yan, H | + | [[Category: Yan, H]] |
[[Category: 8-dihydroneopterin]] | [[Category: 8-dihydroneopterin]] | ||
[[Category: Atomic resolution]] | [[Category: Atomic resolution]] | ||
[[Category: Dhna]] | [[Category: Dhna]] | ||
| - | [[Category: Dihydroneopterin aldolase]] | ||
[[Category: Drug design]] | [[Category: Drug design]] | ||
[[Category: Lyase]] | [[Category: Lyase]] | ||
[[Category: Monapterin]] | [[Category: Monapterin]] | ||
[[Category: Neopterin]] | [[Category: Neopterin]] | ||
Revision as of 19:07, 25 December 2014
Atomic resolution crystal structure of E.coli dihydroneopterin aldolase in complex with neopterin
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