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3mxo
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxo RCSB], [http://www.ebi.ac.uk/pdbsum/3mxo PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3mxo RCSB], [http://www.ebi.ac.uk/pdbsum/3mxo PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PGAM5_HUMAN PGAM5_HUMAN]] Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.<ref>PMID:18387606</ref> <ref>PMID:19590015</ref> <ref>PMID:22265414</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Phosphoglycerate Mutase|Phosphoglycerate Mutase]] | *[[Phosphoglycerate Mutase|Phosphoglycerate Mutase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 19:09, 25 December 2014
Crystal structure oh human phosphoglycerate mutase family member 5 (PGAM5)
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Categories: Homo sapiens | Phosphoprotein phosphatase | Alfano, I | Arrowsmith, C H | Barr, A | Bountra, C | Chaikuad, A | Delft, F von | Edwards, A M | Filippakopoulos, P | Ichijo, H | Knapp, S | Picaud, S | Structural genomic | Takeda, K | Weigelt, J | Bxlbv68 | Hydrolase | Mgc5352 protein | Pgam5 | Phosphoglycerate mutase family member 5 | Sgc
