3hm5
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hm5 RCSB], [http://www.ebi.ac.uk/pdbsum/3hm5 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3hm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3hm5 RCSB], [http://www.ebi.ac.uk/pdbsum/3hm5 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DMAP1_HUMAN DMAP1_HUMAN]] Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity.<ref>PMID:14665632</ref> <ref>PMID:14978102</ref> <ref>PMID:14966270</ref> <ref>PMID:15367675</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 19:13, 25 December 2014
SANT domain of human DNA methyltransferase 1 associated protein 1
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Categories: Homo sapiens | Amaya, M F | Arrowsmith, C H | Bochkarev, A | Bountra, C | Dombrovski, L | Edwards, A M | Min, J | Ni, S | Park, H | Structural genomic | Tempel, W | Tong, Y | Weigelt, J | Wu, H | Activator | Chromatin | Chromatin regulator | Dna methylation | Growth regulation | Nucleus | Phosphoprotein | Repressor | Sgc | Transcription | Transcription regulation
