This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2p4v
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2p4v]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P4V FirstGlance]. <br> | <table><tr><td colspan='2'>[[2p4v]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P4V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2P4V FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1grj|1grj]], [[2eul|2eul]], [[2etn|2etn]], [[2f23|2f23]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1grj|1grj]], [[2eul|2eul]], [[2etn|2etn]], [[2f23|2f23]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">greB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">greB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p4v RCSB], [http://www.ebi.ac.uk/pdbsum/2p4v PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p4v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p4v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2p4v RCSB], [http://www.ebi.ac.uk/pdbsum/2p4v PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GREB_ECOL6 GREB_ECOL6]] Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 35: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
| - | [[Category: Artsimovitch, I | + | [[Category: Artsimovitch, I]] |
| - | [[Category: Dearborn, A D | + | [[Category: Dearborn, A D]] |
| - | [[Category: Klyuyev, S | + | [[Category: Klyuyev, S]] |
| - | [[Category: Svetlov, V | + | [[Category: Svetlov, V]] |
| - | [[Category: Vassylyev, D G | + | [[Category: Vassylyev, D G]] |
| - | [[Category: Vassylyeva, M N | + | [[Category: Vassylyeva, M N]] |
[[Category: Gre-factor]] | [[Category: Gre-factor]] | ||
[[Category: Rna polymerase]] | [[Category: Rna polymerase]] | ||
[[Category: Transcript cleavage]] | [[Category: Transcript cleavage]] | ||
[[Category: Transcription]] | [[Category: Transcription]] | ||
Revision as of 19:20, 25 December 2014
Crystal structure of the transcript cleavage factor, GreB at 2.6A resolution
| |||||||||||
