This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1hyl
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1hyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hypoderma_lineatum Hypoderma lineatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HYL FirstGlance]. <br> | <table><tr><td colspan='2'>[[1hyl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hypoderma_lineatum Hypoderma lineatum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HYL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hyl RCSB], [http://www.ebi.ac.uk/pdbsum/1hyl PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hyl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1hyl RCSB], [http://www.ebi.ac.uk/pdbsum/1hyl PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/COGS_HYPLI COGS_HYPLI]] This enzyme is a serine protease capable of degrading the native triple helix of collagen. Also cleaves the B chain of insulin at the 15-Leu-|-Try-16 and 22-Arg-|-Gly-23 bonds. Hydrolyzes casein, but not Px-Pro-Leu-Gly-Pro-DArg, BzArgNHPh, AcTyrNHPh, 2-naphthyl phosphate, 2-naphthyl butyrate, 2-naphthyl caprylate, 2-naphthyl myristate, L-leucine 2-2-naphthylamide, L-valine 2-naphthylamide, L-cysteine 2-naphthylamide or L-glutarylphenylalanine 2-naphthylamide.<ref>PMID:230030</ref> <ref>PMID:2995028</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 28: | Line 30: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Hypoderma lineatum]] | [[Category: Hypoderma lineatum]] | ||
| - | [[Category: Arnoux, B | + | [[Category: Arnoux, B]] |
| - | [[Category: Broutin, I | + | [[Category: Broutin, I]] |
| - | [[Category: Ducruix, A | + | [[Category: Ducruix, A]] |
| - | [[Category: Keil, B | + | [[Category: Keil, B]] |
| - | [[Category: Lecroisey, A | + | [[Category: Lecroisey, A]] |
| - | [[Category: Pascard, C | + | [[Category: Pascard, C]] |
| - | [[Category: Riche, C | + | [[Category: Riche, C]] |
Revision as of 19:45, 25 December 2014
THE 1.8 A STRUCTURE OF COLLAGENASE FROM HYPODERMA LINEATUM
| |||||||||||
