4gv9
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gv9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gv9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gv9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gv9 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NCAP_LASSJ NCAP_LASSJ]] Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFN-beta) production. Strongly inhibits the nuclear translocation of IRF3, a protein involved in IFN activation pathway. Also inhibits the activation of IFN-beta and IRF3-dependent promoters (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 19:49, 25 December 2014
Lassa nucleoprotein C-terminal domain in complex with triphosphated dsRNA soaking for 5 min
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