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3ddt
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [http://www.ebi.ac.uk/pdbsum/3ddt PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ddt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ddt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ddt RCSB], [http://www.ebi.ac.uk/pdbsum/3ddt PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRI63_HUMAN TRI63_HUMAN]] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.<ref>PMID:11927605</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 19:50, 25 December 2014
Crystal structure of the B2 box from MuRF1 in dimeric state
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