1j5i
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1j5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J5I FirstGlance]. <br> | <table><tr><td colspan='2'>[[1j5i]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1J5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1J5I FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCZ:2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC+ACID+MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL+ESTER'>NCZ</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NCZ:2-HYDROXY-7-METHOXY-5-METHYL-NAPHTHALENE-1-CARBOXYLIC+ACID+MESO-2,5-DIHYDROXY-CYCLOPENT-3-ENYL+ESTER'>NCZ</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j5i RCSB], [http://www.ebi.ac.uk/pdbsum/1j5i PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j5i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1j5i RCSB], [http://www.ebi.ac.uk/pdbsum/1j5i PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NCZS_STRCZ NCZS_STRCZ]] NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Streptomyces carzinostaticus]] | [[Category: Streptomyces carzinostaticus]] | ||
| - | [[Category: Caddick, S | + | [[Category: Caddick, S]] |
| - | [[Category: Finucane, M D | + | [[Category: Finucane, M D]] |
| - | [[Category: Muskett, F W | + | [[Category: Muskett, F W]] |
| - | [[Category: Urbaniak, M D | + | [[Category: Urbaniak, M D]] |
| - | [[Category: Woolfson, D N | + | [[Category: Woolfson, D N]] |
[[Category: Antibiotic]] | [[Category: Antibiotic]] | ||
[[Category: Beta sandwich]] | [[Category: Beta sandwich]] | ||
Revision as of 19:53, 25 December 2014
Solution Structure of a Novel Chromoprotein Derived from Apo-Neocarzinostatin and a Synthetic Chromophore
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