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1zl7
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1zl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZL7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1zl7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararacussu Bothrops jararacussu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZL7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZL7 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1umv|1umv]], [[1zlb|1zlb]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1umv|1umv]], [[1zlb|1zlb]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zl7 RCSB], [http://www.ebi.ac.uk/pdbsum/1zl7 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zl7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zl7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zl7 RCSB], [http://www.ebi.ac.uk/pdbsum/1zl7 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q8AXY1_BOTJR Q8AXY1_BOTJR]] Snake venom phospholipase A2 (PLA2) that induces edema (activity that is inhibited by EDTA and dexamethasone), inhibits phospholipid-dependent collagen/ADP-induced platelet aggregation, possess hypotensive as well as anticoagulant activities. In addition, this enzyme shows bactericidal activity against E.coli and S.aureus. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.<ref>PMID:15214498</ref> <ref>PMID:12167491</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Bothrops jararacussu]] | [[Category: Bothrops jararacussu]] | ||
| - | [[Category: Arni, R K | + | [[Category: Arni, R K]] |
| - | [[Category: Betzel, C | + | [[Category: Betzel, C]] |
| - | [[Category: Cintra, A C | + | [[Category: Cintra, A C]] |
| - | [[Category: Gabdoulkhakov, A | + | [[Category: Gabdoulkhakov, A]] |
| - | [[Category: Genov, N | + | [[Category: Genov, N]] |
| - | [[Category: Murakami, M T | + | [[Category: Murakami, M T]] |
[[Category: Asp49-pla2]] | [[Category: Asp49-pla2]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Snake venom]] | [[Category: Snake venom]] | ||
Revision as of 19:53, 25 December 2014
Crystal structure of catalytically-active phospholipase A2 with bound calcium
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