3qsb
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3qsb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QSB FirstGlance]. <br> | <table><tr><td colspan='2'>[[3qsb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QSB FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=743:(1R,5R)-5-{(1Z)-N-[(4-FLUOROBIPHENYL-4-YL)METHOXY]BUTANIMIDOYL}-2,2-DIMETHYL-4,6-DIOXOCYCLOHEXANECARBONITRILE'>743</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=743:(1R,5R)-5-{(1Z)-N-[(4-FLUOROBIPHENYL-4-YL)METHOXY]BUTANIMIDOYL}-2,2-DIMETHYL-4,6-DIOXOCYCLOHEXANECARBONITRILE'>743</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mmi|1mmi]], [[2pol|2pol]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1mmi|1mmi]], [[2pol|2pol]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dnaN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dnaN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qsb RCSB], [http://www.ebi.ac.uk/pdbsum/3qsb PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3qsb RCSB], [http://www.ebi.ac.uk/pdbsum/3qsb PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Binding Inhibitors of the Bacterial Sliding Clamp by Design.,Wijffels G, Johnson WM, Oakley AJ, Turner K, Epa VC, Briscoe SJ, Polley M, Liepa AJ, Hofmann A, Buchardt J, Christensen C, Prosselkov P, Dalrymple BP, Alewood PF, Jennings PA, Dixon NE, Winkler DA J Med Chem. 2011 May 23. PMID:21604761<ref>PMID:21604761</ref> | Binding Inhibitors of the Bacterial Sliding Clamp by Design.,Wijffels G, Johnson WM, Oakley AJ, Turner K, Epa VC, Briscoe SJ, Polley M, Liepa AJ, Hofmann A, Buchardt J, Christensen C, Prosselkov P, Dalrymple BP, Alewood PF, Jennings PA, Dixon NE, Winkler DA J Med Chem. 2011 May 23. PMID:21604761<ref>PMID:21604761</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[DNA polymerase|DNA polymerase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
[[Category: Ecoli]] | [[Category: Ecoli]] | ||
| - | [[Category: Alewood, P F | + | [[Category: Alewood, P F]] |
| - | [[Category: Briscoe, S J | + | [[Category: Briscoe, S J]] |
| - | [[Category: Buchardt, J | + | [[Category: Buchardt, J]] |
| - | [[Category: Christensen, C | + | [[Category: Christensen, C]] |
| - | [[Category: Dalrymple, B P | + | [[Category: Dalrymple, B P]] |
| - | [[Category: Dixon, N E | + | [[Category: Dixon, N E]] |
| - | [[Category: Epa, V C | + | [[Category: Epa, V C]] |
| - | [[Category: Hofmann, A | + | [[Category: Hofmann, A]] |
| - | [[Category: Jennings, P A | + | [[Category: Jennings, P A]] |
| - | [[Category: Johnson, W M | + | [[Category: Johnson, W M]] |
| - | [[Category: Liepa, A J | + | [[Category: Liepa, A J]] |
| - | [[Category: Oakley, A J | + | [[Category: Oakley, A J]] |
| - | [[Category: Polley, M | + | [[Category: Polley, M]] |
| - | [[Category: Prosselkov, P | + | [[Category: Prosselkov, P]] |
| - | [[Category: Turner, K | + | [[Category: Turner, K]] |
| - | [[Category: Wijffels, G | + | [[Category: Wijffels, G]] |
| - | [[Category: Winkler, D A | + | [[Category: Winkler, D A]] |
[[Category: Dna replication]] | [[Category: Dna replication]] | ||
[[Category: Dnan]] | [[Category: Dnan]] | ||
[[Category: Sliding clamp]] | [[Category: Sliding clamp]] | ||
[[Category: Transferase-transferase inhibitor complex]] | [[Category: Transferase-transferase inhibitor complex]] | ||
Revision as of 19:56, 25 December 2014
Structure of E. coli polIIIbeta with (Z)-5-(1-((4'-Fluorobiphenyl-4-yl)methoxyimino)butyl)-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile
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Categories: DNA-directed DNA polymerase | Ecoli | Alewood, P F | Briscoe, S J | Buchardt, J | Christensen, C | Dalrymple, B P | Dixon, N E | Epa, V C | Hofmann, A | Jennings, P A | Johnson, W M | Liepa, A J | Oakley, A J | Polley, M | Prosselkov, P | Turner, K | Wijffels, G | Winkler, D A | Dna replication | Dnan | Sliding clamp | Transferase-transferase inhibitor complex
