3tbw

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[[Image:3tbw.jpg|left|200px]]
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==CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (A2G, V3P, Y4S)==
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<StructureSection load='3tbw' size='340' side='right' caption='[[3tbw]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3tbw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TBW FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[3qul|3qul]], [[3quk|3quk]], [[3tbs|3tbs]], [[3tbt|3tbt]], [[3tbv|3tbv]], [[3tbx|3tbx]], [[3tby|3tby]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">H2-D1, H2-DB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), B2m ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tbw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3tbw RCSB], [http://www.ebi.ac.uk/pdbsum/3tbw PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity). Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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{{STRUCTURE_3tbw| PDB=3tbw | SCENE= }}
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==See Also==
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*[[Beta-2 microglobulin|Beta-2 microglobulin]]
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===CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (A2G, V3P, Y4S)===
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*[[Major histocompatibility complex|Major histocompatibility complex]]
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__TOC__
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</StructureSection>
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==About this Structure==
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[[3tbw]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBW OCA].
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Achour, A.]]
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[[Category: Achour, A]]
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[[Category: Allerbring, E B.]]
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[[Category: Allerbring, E B]]
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[[Category: Badia-Martinez, D.]]
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[[Category: Badia-Martinez, D]]
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[[Category: Duru, A D.]]
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[[Category: Duru, A D]]
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[[Category: Madhurantakam, C.]]
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[[Category: Madhurantakam, C]]
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[[Category: Mazumdar, P A.]]
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[[Category: Mazumdar, P A]]
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[[Category: Nygren, P.]]
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[[Category: Nygren, P]]
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[[Category: Sandalova, T.]]
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[[Category: Sandalova, T]]
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[[Category: Uchtenhagen, H.]]
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[[Category: Uchtenhagen, H]]
[[Category: Agonism]]
[[Category: Agonism]]
[[Category: Altered peptide ligand]]
[[Category: Altered peptide ligand]]

Revision as of 20:06, 25 December 2014

CRYSTAL STRUCTURE OF THE MURINE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX H-2DB IN COMPLEX WITH THE LCMV-DERIVED GP33 ALTERED PEPTIDE ligand (A2G, V3P, Y4S)

3tbw, resolution 2.15Å

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