2f44

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[[Image:2f44.gif|left|200px]]<br /><applet load="2f44" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2f44.gif|left|200px]]
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caption="2f44, resolution 2.4&Aring;" />
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'''Crystal Structure of the Zinc-bound Shank SAM domain'''<br />
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{{Structure
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|PDB= 2f44 |SIZE=350|CAPTION= <scene name='initialview01'>2f44</scene>, resolution 2.4&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene>
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|ACTIVITY=
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|GENE= Shank3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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}}
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'''Crystal Structure of the Zinc-bound Shank SAM domain'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2F44 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F44 OCA].
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2F44 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F44 OCA].
==Reference==
==Reference==
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An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16439662 16439662]
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An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16439662 16439662]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: zinc]]
[[Category: zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:17:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:47:52 2008''

Revision as of 14:47, 20 March 2008

Image:2f44.gif


PDB ID 2f44

Drag the structure with the mouse to rotate
, resolution 2.4Å
Ligands: and
Gene: Shank3 (Rattus norvegicus)
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of the Zinc-bound Shank SAM domain


Overview

The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.

About this Structure

2F44 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

An architectural framework that may lie at the core of the postsynaptic density., Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya MR, Salyer D, Gundelfinger ED, Bowie JU, Science. 2006 Jan 27;311(5760):531-5. PMID:16439662

Page seeded by OCA on Thu Mar 20 16:47:52 2008

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