4lwt
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4lwt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LWT FirstGlance]. <br> | <table><tr><td colspan='2'>[[4lwt]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LWT FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=20Q:(3S)-3-[(3R)-1-ACETYLPIPERIDIN-3-YL]-6-CHLORO-3-(3-CHLOROBENZYL)-1,3-DIHYDRO-2H-INDOL-2-ONE'>20Q</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=20Q:(3S)-3-[(3R)-1-ACETYLPIPERIDIN-3-YL]-6-CHLORO-3-(3-CHLOROBENZYL)-1,3-DIHYDRO-2H-INDOL-2-ONE'>20Q</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lwu|4lwu]], [[4lwv|4lwv]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lwu|4lwu]], [[4lwv|4lwv]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lwt RCSB], [http://www.ebi.ac.uk/pdbsum/4lwt PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lwt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lwt RCSB], [http://www.ebi.ac.uk/pdbsum/4lwt PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Graves, B J | + | [[Category: Graves, B J]] |
| - | [[Category: Kammlott, U | + | [[Category: Kammlott, U]] |
| - | [[Category: Lukacs, C | + | [[Category: Lukacs, C]] |
[[Category: E3 ubiquitin ligase]] | [[Category: E3 ubiquitin ligase]] | ||
[[Category: Indolinone]] | [[Category: Indolinone]] | ||
Revision as of 20:20, 25 December 2014
The 1.6A Crystal Structure of Humanized Xenopus MDM2 with RO5027344
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