4gv5
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==X-ray structure of crotamine, a cell-penetrating peptide from the Brazilian snake Crotalus durissus terrificus== | |
| - | + | <StructureSection load='4gv5' size='340' side='right' caption='[[4gv5]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4gv5]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Crodu Crodu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4GV5 FirstGlance]. <br> | |
| - | ==Function== | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gv5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4gv5 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/MYXC_CRODU MYXC_CRODU]] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.<ref>PMID:1176086</ref> <ref>PMID:9839677</ref> | [[http://www.uniprot.org/uniprot/MYXC_CRODU MYXC_CRODU]] This toxin specifically modifies voltage-gated sodium channels (Nav), it exhibits analgesic activity and causes severe muscle necrosis by a non-enzymatic mechanism. Moreover, it actively interacts with lipid membranes.<ref>PMID:1176086</ref> <ref>PMID:9839677</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The crystal structure of the myotoxic, cell-penetrating, basic polypeptide crotamine isolated from the venom of Crotalus durissus terrificus has been determined by single-wavelength anomalous dispersion techniques and refined at 1.7 A resolution. The structure reveals distinct cationic and hydrophobic surface regions that are located on opposite sides of the molecule. This surface-charge distribution indicates its possible mode of interaction with negatively charged phospholipids and other molecular targets to account for its diverse pharmacological activities. Although the sequence identity between crotamine and human beta-defensins is low, the three-dimensional structures of these functionally related peptides are similar. Since crotamine is a leading member of a large family of myotoxic peptides, its structure will provide a basis for the design of novel cell-penetrating molecules. | ||
| + | |||
| + | Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus.,Coronado MA, Gabdulkhakov A, Georgieva D, Sankaran B, Murakami MT, Arni RK, Betzel C Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):1958-64. doi:, 10.1107/S0907444913018003. Epub 2013 Sep 20. PMID:24100315<ref>PMID:24100315</ref> | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | == | + | ==See Also== |
| - | + | *[[Crotamine|Crotamine]] | |
| - | [[Category: | + | == References == |
| - | [[Category: Arni, R K | + | <references/> |
| - | [[Category: Betzel, C | + | __TOC__ |
| - | [[Category: Coronado, M A | + | </StructureSection> |
| - | [[Category: Gabdulkhakov, A | + | [[Category: Crodu]] |
| - | [[Category: Georgieva, D | + | [[Category: Arni, R K]] |
| - | [[Category: Murakami, M T | + | [[Category: Betzel, C]] |
| - | [[Category: Sankaran, B | + | [[Category: Coronado, M A]] |
| + | [[Category: Gabdulkhakov, A]] | ||
| + | [[Category: Georgieva, D]] | ||
| + | [[Category: Murakami, M T]] | ||
| + | [[Category: Sankaran, B]] | ||
[[Category: Alpha helix & beta sheet]] | [[Category: Alpha helix & beta sheet]] | ||
[[Category: Antibacterial peptide]] | [[Category: Antibacterial peptide]] | ||
Revision as of 20:21, 25 December 2014
X-ray structure of crotamine, a cell-penetrating peptide from the Brazilian snake Crotalus durissus terrificus
| |||||||||||
