2y7q
From Proteopedia
(Difference between revisions)
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<StructureSection load='2y7q' size='340' side='right' caption='[[2y7q]], [[Resolution|resolution]] 3.40Å' scene=''> | <StructureSection load='2y7q' size='340' side='right' caption='[[2y7q]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y7q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7Q OCA]. <br> | + | <table><tr><td colspan='2'>[[2y7q]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y7Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2Y7Q FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fp5|1fp5]], [[1f6a|1f6a]], [[1j87|1j87]], [[1o0v|1o0v]], [[1j88|1j88]], [[1j86|1j86]], [[1j89|1j89]], [[1g84|1g84]], [[1ige|1ige]], [[1rpq|1rpq]], [[1f2q|1f2q]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fp5|1fp5]], [[1f6a|1f6a]], [[1j87|1j87]], [[1o0v|1o0v]], [[1j88|1j88]], [[1j86|1j86]], [[1j89|1j89]], [[1g84|1g84]], [[1ige|1ige]], [[1rpq|1rpq]], [[1f2q|1f2q]]</td></tr> |
| - | <tr | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2y7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y7q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2y7q RCSB], [http://www.ebi.ac.uk/pdbsum/2y7q PDBsum]</span></td></tr> |
| - | + | </table> | |
| - | <table> | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/FCERA_HUMAN FCERA_HUMAN]] Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcvarepsilonRI.,Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ Nat Struct Mol Biol. 2011 May;18(5):571-6. Epub 2011 Apr 24. PMID:21516097<ref>PMID:21516097</ref> | Conformational changes in IgE contribute to its uniquely slow dissociation rate from receptor FcvarepsilonRI.,Holdom MD, Davies AM, Nettleship JE, Bagby SC, Dhaliwal B, Girardi E, Hunt J, Gould HJ, Beavil AJ, McDonnell JM, Owens RJ, Sutton BJ Nat Struct Mol Biol. 2011 May;18(5):571-6. Epub 2011 Apr 24. PMID:21516097<ref>PMID:21516097</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Beavil, A J | + | [[Category: Beavil, A J]] |
| - | [[Category: Davies, A M | + | [[Category: Davies, A M]] |
| - | [[Category: Holdom, M D | + | [[Category: Holdom, M D]] |
| - | [[Category: Nettleship, J E | + | [[Category: Nettleship, J E]] |
| - | [[Category: Owens, R J | + | [[Category: Owens, R J]] |
| - | [[Category: Sutton, B J | + | [[Category: Sutton, B J]] |
[[Category: Allergy]] | [[Category: Allergy]] | ||
[[Category: Antibody]] | [[Category: Antibody]] | ||
Revision as of 20:40, 25 December 2014
THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI
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