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2c9f
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2c9f]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C9F FirstGlance]. <br> | <table><tr><td colspan='2'>[[2c9f]] is a 10 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C9F FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x9p|1x9p]], [[1x9t|1x9t]], [[2bld|2bld]], [[2bvi|2bvi]], [[2c6s|2c6s]], [[2c9g|2c9g]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1x9p|1x9p]], [[1x9t|1x9t]], [[2bld|2bld]], [[2bvi|2bvi]], [[2c6s|2c6s]], [[2c9g|2c9g]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c9f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c9f RCSB], [http://www.ebi.ac.uk/pdbsum/2c9f PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c9f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c9f RCSB], [http://www.ebi.ac.uk/pdbsum/2c9f PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PEN3_ADE02 PEN3_ADE02]] Major capsid protein that self-associates to form penton base pentamers, each in the shape of a pentagon, situated at the 12 vertices of the pseudo T=25 capsid. Involved in virus secondary attachment to host cell after initial attachment by the fiber protein. Binds host integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering clathrin-mediated endocytosis of virions. Mediates initial virus attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5 also seems to induce macropinocytosis uptake of the virus. As the virus enters the host cell, penton proteins are shed concomitant with virion acidification in the endosome.<ref>PMID:12221069</ref> <ref>PMID:20615244</ref> <ref>PMID:20798312</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human adenovirus 2]] | [[Category: Human adenovirus 2]] | ||
| - | [[Category: Chroboczek, J | + | [[Category: Chroboczek, J]] |
| - | [[Category: Conway, J F | + | [[Category: Conway, J F]] |
| - | [[Category: Fabry, C M.S | + | [[Category: Fabry, C M.S]] |
| - | [[Category: Fender, P | + | [[Category: Fender, P]] |
| - | [[Category: Fuschiotti, P | + | [[Category: Fuschiotti, P]] |
| - | [[Category: Hewat, E A | + | [[Category: Hewat, E A]] |
| - | [[Category: Ruigrok, R W.H | + | [[Category: Ruigrok, R W.H]] |
| - | [[Category: Schoehn, G | + | [[Category: Schoehn, G]] |
[[Category: Dodecahedron]] | [[Category: Dodecahedron]] | ||
[[Category: Fibre]] | [[Category: Fibre]] | ||
[[Category: Penton]] | [[Category: Penton]] | ||
[[Category: Virus-viral protein complex]] | [[Category: Virus-viral protein complex]] | ||
Revision as of 20:42, 25 December 2014
THE QUASI-ATOMIC MODEL OF THE ADENOVIRUS TYPE 3 PENTON DODECAHEDRON
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