2f8y

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[[Image:2f8y.gif|left|200px]]<br /><applet load="2f8y" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2f8y.gif|left|200px]]
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caption="2f8y, resolution 1.55&Aring;" />
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'''Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.'''<br />
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{{Structure
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|PDB= 2f8y |SIZE=350|CAPTION= <scene name='initialview01'>2f8y</scene>, resolution 1.55&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE= Notch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2F8Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8Y OCA].
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2F8Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8Y OCA].
==Reference==
==Reference==
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Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes., Nam Y, Sliz P, Song L, Aster JC, Blacklow SC, Cell. 2006 Mar 10;124(5):973-83. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16530044 16530044]
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Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes., Nam Y, Sliz P, Song L, Aster JC, Blacklow SC, Cell. 2006 Mar 10;124(5):973-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16530044 16530044]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Sliz, P.]]
[[Category: Sliz, P.]]
[[Category: SO4]]
[[Category: SO4]]
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[[Category: ankyrin repeats]]
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[[Category: ankyrin repeat]]
[[Category: notch]]
[[Category: notch]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:18:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:49:31 2008''

Revision as of 14:49, 20 March 2008

Image:2f8y.gif


PDB ID 2f8y

Drag the structure with the mouse to rotate
, resolution 1.55Å
Ligands:
Gene: Notch1 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.


Contents

Overview

Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon activation. We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). Together, CSL and ANK create a groove to bind the MAML-1 polypeptide as a kinked, 70 A helix. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of Notch target genes.

Disease

Known diseases associated with this structure: Aortic valve disease OMIM:[190198], Leukemia, T-cell acute lymphoblastic OMIM:[190198]

About this Structure

2F8Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes., Nam Y, Sliz P, Song L, Aster JC, Blacklow SC, Cell. 2006 Mar 10;124(5):973-83. PMID:16530044

Page seeded by OCA on Thu Mar 20 16:49:31 2008

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