2f9a

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[[Image:2f9a.gif|left|200px]]<br /><applet load="2f9a" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2f9a.gif|left|200px]]
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caption="2f9a, resolution 2.51&Aring;" />
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'''HMG-CoA synthase from Brassica juncea in complex with F-244'''<br />
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{{Structure
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|PDB= 2f9a |SIZE=350|CAPTION= <scene name='initialview01'>2f9a</scene>, resolution 2.51&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=F24:(3R,5S,7R,12S,13R)-13-FORMYL-12,14-DIHYDROXY-3,5,7-TRIMETHYLTETRADECANOIC ACID'>F24</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''HMG-CoA synthase from Brassica juncea in complex with F-244'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2F9A is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea] with <scene name='pdbligand=F24:'>F24</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9A OCA].
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2F9A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brassica_juncea Brassica juncea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F9A OCA].
==Reference==
==Reference==
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Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases., Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP, Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16864776 16864776]
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Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases., Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP, Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16864776 16864776]
[[Category: Brassica juncea]]
[[Category: Brassica juncea]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: hmgs1]]
[[Category: hmgs1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:19:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:49:40 2008''

Revision as of 14:49, 20 March 2008

Image:2f9a.gif


PDB ID 2f9a

Drag the structure with the mouse to rotate
, resolution 2.51Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



HMG-CoA synthase from Brassica juncea in complex with F-244


Overview

3-Hydroxy-3-methylglutaryl CoA synthase (HMGS) catalyzes the first committed step in the mevalonate metabolic pathway for isoprenoid biosynthesis and serves as an alternative target for cholesterol-lowering and antibiotic drugs. We have determined a previously undescribed crystal structure of a eukaryotic HMGS bound covalently to a potent and specific inhibitor F-244 [(E,E)-11-[3-(hydroxymethyl)-4-oxo-2-oxytanyl]-3,5,7-trimethyl-2,4-undecad ienenoic acid]. Given the accessibility of synthetic analogs of the F-244 natural product, this inhibited eukaryotic HMGS structure serves as a necessary starting point for structure-based methods that may improve the potency and species-specific selectivity of the next generation of F-244 analogs designed to target particular eukaryotic and prokaryotic HMGS.

About this Structure

2F9A is a Single protein structure of sequence from Brassica juncea. Full crystallographic information is available from OCA.

Reference

Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases., Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP, Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11491-6. Epub 2006 Jul 24. PMID:16864776

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