3k1o
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3k1o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K1O FirstGlance]. <br> | <table><tr><td colspan='2'>[[3k1o]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3K1O FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=POZ:2,5-ANHYDRO-1,3,4-TRIDEOXY-2-(2,4-DIFLUOROPHENYL)-6-O-{4-[4-(4-{1-[(1S,2S)-1-ETHYL-2-HYDROXYPROPYL]-5-OXO-1,5-DIHYDRO-4H-1,2,4-TRIAZOL-4-YL}PHENYL)PIPERAZIN-1-YL]PHENYL}-1-(1H-1,2,4-TRIAZOL-1-YL)-D-ERYTHRO-HEXITOL'>POZ</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=POZ:2,5-ANHYDRO-1,3,4-TRIDEOXY-2-(2,4-DIFLUOROPHENYL)-6-O-{4-[4-(4-{1-[(1S,2S)-1-ETHYL-2-HYDROXYPROPYL]-5-OXO-1,5-DIHYDRO-4H-1,2,4-TRIAZOL-4-YL}PHENYL)PIPERAZIN-1-YL]PHENYL}-1-(1H-1,2,4-TRIAZOL-1-YL)-D-ERYTHRO-HEXITOL'>POZ</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3g1q|3g1q]], [[3i3k|3i3k]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3g1q|3g1q]], [[3i3k|3i3k]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 Trypanosoma cruzi])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP51 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 Trypanosoma cruzi])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k1o RCSB], [http://www.ebi.ac.uk/pdbsum/3k1o PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3k1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k1o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3k1o RCSB], [http://www.ebi.ac.uk/pdbsum/3k1o PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CP51_TRYCR CP51_TRYCR]] Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity). Favors C4 dimethylated substrates, the substrate preference order is 24-methylenedihydrolanosterol > 24,25-dihydrolanosterol > lanosterol > obtusifoliol > norlanosterol.<ref>PMID:16321980</ref> [UniProtKB:P0A512] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi.,Lepesheva GI, Hargrove TY, Anderson S, Kleshchenko Y, Furtak V, Wawrzak Z, Villalta F, Waterman MR J Biol Chem. 2010 Aug 13;285(33):25582-90. Epub 2010 Jun 8. PMID:20530488<ref>PMID:20530488</ref> | Structural insights into inhibition of sterol 14alpha-demethylase in the human pathogen Trypanosoma cruzi.,Lepesheva GI, Hargrove TY, Anderson S, Kleshchenko Y, Furtak V, Wawrzak Z, Villalta F, Waterman MR J Biol Chem. 2010 Aug 13;285(33):25582-90. Epub 2010 Jun 8. PMID:20530488<ref>PMID:20530488</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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[[Category: Sterol 14-demethylase]] | [[Category: Sterol 14-demethylase]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
| - | [[Category: Anderson, S | + | [[Category: Anderson, S]] |
| - | [[Category: Hargrove, T Y | + | [[Category: Hargrove, T Y]] |
[[Category: Lepesheva, G I]] | [[Category: Lepesheva, G I]] | ||
| - | [[Category: Waterman, M R | + | [[Category: Waterman, M R]] |
| - | [[Category: Wawrzak, Z | + | [[Category: Wawrzak, Z]] |
[[Category: Cyp51]] | [[Category: Cyp51]] | ||
[[Category: Cytochrome p450]] | [[Category: Cytochrome p450]] | ||
Revision as of 20:46, 25 December 2014
Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi in complex with a potential antichagasic drug, posaconazole
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Categories: Sterol 14-demethylase | Trypanosoma cruzi | Anderson, S | Hargrove, T Y | Lepesheva, G I | Waterman, M R | Wawrzak, Z | Cyp51 | Cytochrome p450 | Eburicol 14a-demethylase | Endoplasmic reticulum | Heme | Heme-thiolate protein | Iron | Lipid | Membrane | Monooxygenase | Oxidoreductase | Sterol 14-alpha demethylase | Sterol biosynthesis | Transmembrane protein
