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2kz8
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz8 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kz8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kz8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kz8 RCSB], [http://www.ebi.ac.uk/pdbsum/2kz8 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/YGIT_ECOLI YGIT_ECOLI]] Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that binds to the MqsR mRNA interferase toxin and neutralizes its endoribonuclease activity. Overexpression prevents MqsR-mediated cessation of cell growth and inhibition of cell proliferation. Overexpression also increases biofilm formation, perhaps by repressing cspD.<ref>PMID:19690171</ref> <ref>PMID:20105222</ref> <ref>PMID:19943910</ref> Also acts as a transcription factor. Both MqsA and MqsRA bind to the promoter region of the mqsRA operon, inactivating (PubMed:19943910) or activating (PubMed:20105222) transcription. Alone or in complex with MqsR binds to other promoters, inducing mcbR and spy and repressing cspD among others.<ref>PMID:19690171</ref> <ref>PMID:20105222</ref> <ref>PMID:19943910</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 20:50, 25 December 2014
Solution NMR structure of MqsA, a protein from E. coli, containing a Zinc finger, N-terminal and a Helix Turn-Helix C-terminal domain
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