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3fqd
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fqd RCSB], [http://www.ebi.ac.uk/pdbsum/3fqd PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3fqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fqd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3fqd RCSB], [http://www.ebi.ac.uk/pdbsum/3fqd PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/XRN2_SCHPO XRN2_SCHPO]] Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II (By similarity). Essential for vegetative cell growth and chromosome segregation. Possesses 5'->3' exoribonuclease activity. [[http://www.uniprot.org/uniprot/DOM3Z_SCHPO DOM3Z_SCHPO]] Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA (By similarity). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of rat1, allowing it to degrade RNAs with stable secondary structure more effectively.<ref>PMID:19194460</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 20:51, 25 December 2014
Crystal Structure of the S. pombe Rat1-Rai1 Complex
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