4v24
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [http://www.ebi.ac.uk/pdbsum/4v24 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v24 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v24 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v24 RCSB], [http://www.ebi.ac.uk/pdbsum/4v24 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPHK1_HUMAN SPHK1_HUMAN]] Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol.<ref>PMID:20577214</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Sphinganine kinase]] | [[Category: Sphinganine kinase]] | ||
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Elkins, J M | + | [[Category: Elkins, J M]] |
| - | [[Category: Knapp, S | + | [[Category: Knapp, S]] |
| - | [[Category: Shrestha, L | + | [[Category: Shrestha, L]] |
| - | [[Category: Sorrell, F | + | [[Category: Sorrell, F]] |
| - | [[Category: Tallant, C | + | [[Category: Tallant, C]] |
| - | [[Category: Wang, D | + | [[Category: Wang, D]] |
| - | [[Category: Wang, J | + | [[Category: Wang, J]] |
| - | [[Category: VonDelft, F | + | [[Category: VonDelft, F]] |
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Sphingosine]] | [[Category: Sphingosine]] | ||
[[Category: Sphk1]] | [[Category: Sphk1]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 20:52, 25 December 2014
Sphingosine kinase 1 in complex with PF-543
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Categories: Sphinganine kinase | Bountra, C | Edwards, A | Elkins, J M | Knapp, S | Shrestha, L | Sorrell, F | Tallant, C | Wang, D | Wang, J | VonDelft, F | Kinase | Sphingosine | Sphk1 | Transferase
