2fau

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[[Image:2fau.gif|left|200px]]<br /><applet load="2fau" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:2fau.gif|left|200px]]
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caption="2fau, resolution 2.10&Aring;" />
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'''Crystal structure of human vps26'''<br />
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{{Structure
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|PDB= 2fau |SIZE=350|CAPTION= <scene name='initialview01'>2fau</scene>, resolution 2.10&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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|ACTIVITY=
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|GENE= VPS26A, VPS26 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''Crystal structure of human vps26'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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2FAU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FAU OCA].
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2FAU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FAU OCA].
==Reference==
==Reference==
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The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain., Shi H, Rojas R, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Jun;13(6):540-8. Epub 2006 May 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16732284 16732284]
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The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain., Shi H, Rojas R, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Jun;13(6):540-8. Epub 2006 May 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16732284 16732284]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: retromer]]
[[Category: retromer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:19:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:50:10 2008''

Revision as of 14:50, 20 March 2008

Image:2fau.gif


PDB ID 2fau

Drag the structure with the mouse to rotate
, resolution 2.10Å
Ligands:
Gene: VPS26A, VPS26 (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



Crystal structure of human vps26


Overview

The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. The structure of human Vps26A at 2.1-A resolution reveals two curved beta-sandwich domains connected by a polar core and a flexible linker. Vps26 has an unpredicted structural relationship to arrestins. The Vps35-binding site on Vps26 maps to a mobile loop spanning residues 235-246, near the tip of the C-terminal domain. The loop is phylogenetically conserved and provides a mechanism for Vps26 integration into the complex that leaves the rest of the structure free for engagements with membranes and for conformational changes. Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting.

About this Structure

2FAU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain., Shi H, Rojas R, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Jun;13(6):540-8. Epub 2006 May 28. PMID:16732284

Page seeded by OCA on Thu Mar 20 16:50:10 2008

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