2fcb
From Proteopedia
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| - | [[Image:2fcb.gif|left|200px]] | + | [[Image:2fcb.gif|left|200px]] |
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| - | '''HUMAN FC GAMMA RECEPTOR IIB ECTODOMAIN (CD32)''' | + | {{Structure |
| + | |PDB= 2fcb |SIZE=350|CAPTION= <scene name='initialview01'>2fcb</scene>, resolution 1.74Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''HUMAN FC GAMMA RECEPTOR IIB ECTODOMAIN (CD32)''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2FCB is a [ | + | 2FCB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FCB OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution., Sondermann P, Huber R, Jacob U, EMBO J. 1999 Mar 1;18(5):1095-103. PMID:[http:// | + | Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution., Sondermann P, Huber R, Jacob U, EMBO J. 1999 Mar 1;18(5):1095-103. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10064577 10064577] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: receptor]] | [[Category: receptor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:50:39 2008'' |
Revision as of 14:50, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN FC GAMMA RECEPTOR IIB ECTODOMAIN (CD32)
Contents |
Overview
Fcgamma-receptors (FcgammaRs) represent the link between the humoral and cellular immune responses. Via the binding to FcgammaR-positive cells, immunocomplexes trigger several functions such as endocytosis, antibody-dependent cell-mediated cytotoxity (ADCC) and the release of mediators, making them a valuable target for the modulation of the immune system. We solved the crystal structure of the soluble human Fcgamma-receptor IIb (sFcgammaRIIb) to 1.7 A resolution. The structure reveals two typical immunoglobulin (Ig)-like domains enclosing an angle of approximately 70 degrees, leading to a heart-shaped overall structure. In contrast to the observed flexible arrangement of the domains in other members of the Ig superfamily, the two domains are anchored by several hydrogen bonds. The structure reveals that the residues relevant for IgG binding, which were already partially characterized by mutagenesis studies, are located within the BC, C'E and FG loops between the beta-strands of the second domain. Moreover, we discuss a model for the sFcgammaRIIb:IgG complex. In this model, two FcgammaR molecules bind one IgG molecule with their second domains, while the first domain points away from the complex and is therefore available for binding other cell surface molecules, by which potential immunosuppressing functions could be mediated.
Disease
Known diseases associated with this structure: Lupus nephritis, susceptibility to OMIM:[146790], Malaria, resistance to OMIM:[604590], Systemic lupus erythematosus, susceptibility to OMIM:[604590]
About this Structure
2FCB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution., Sondermann P, Huber R, Jacob U, EMBO J. 1999 Mar 1;18(5):1095-103. PMID:10064577
Page seeded by OCA on Thu Mar 20 16:50:39 2008
Categories: Homo sapiens | Single protein | Huber, R. | Jacob, U. | Sondermann, P. | Cd32 | Fc | Receptor
