2l77

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2l77]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L77 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L77 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2l77]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L77 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L77 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2l79|2l79]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2l79|2l79]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l77 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l77 RCSB], [http://www.ebi.ac.uk/pdbsum/2l77 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l77 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l77 RCSB], [http://www.ebi.ac.uk/pdbsum/2l77 PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PPAP_HUMAN PPAP_HUMAN]] A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref> Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling.<ref>PMID:15280042</ref> <ref>PMID:18083097</ref> <ref>PMID:19403677</ref> <ref>PMID:20498373</ref>
==See Also==
==See Also==
*[[Acid phosphatase|Acid phosphatase]]
*[[Acid phosphatase|Acid phosphatase]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acid phosphatase]]
[[Category: Acid phosphatase]]
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[[Category: Brender, J R.]]
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[[Category: Brender, J R]]
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[[Category: Nanga, R.]]
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[[Category: Nanga, R]]
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[[Category: Popovych, N.]]
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[[Category: Popovych, N]]
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[[Category: Ramamoorthy, A.]]
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[[Category: Ramamoorthy, A]]
[[Category: Amyloid]]
[[Category: Amyloid]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Pap248-286]]
[[Category: Pap248-286]]
[[Category: Sevi]]
[[Category: Sevi]]

Revision as of 21:10, 25 December 2014

Solution NMR structure of PAP248-286 in 50% TFE

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