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3iv1
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iv1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iv1 RCSB], [http://www.ebi.ac.uk/pdbsum/3iv1 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3iv1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iv1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3iv1 RCSB], [http://www.ebi.ac.uk/pdbsum/3iv1 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN]] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 21:15, 25 December 2014
Coiled-coil domain of tumor susceptibility gene 101
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Categories: Homo sapiens | Arrowsmith, C H | Avvakumov, G V | Bochkarev, A | Bountra, C | Dhe-Paganon, S | Edwards, A M | Li, Y | Neculai, D | Structural genomic | Walker, J R | Weigelt, J | Wernimont, A K | Xue, S | Cell cycle | Cell division | Cell cycle regulation | Coiled coil | Endosome | Growth regulation | Host-virus interaction | Hydrolase | Membrane | Nucleus | Phosphoprotein | Protein transport | Sgc | Transport | Tumorigenesis
