4nn0
From Proteopedia
(Difference between revisions)
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| - | + | ==Crystal structure of the C1QTNF5 globular domain in space group P63== | |
| - | + | <StructureSection load='4nn0' size='340' side='right' caption='[[4nn0]], [[Resolution|resolution]] 1.42Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4nn0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NN0 FirstGlance]. <br> | |
| - | ==Disease== | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4f3j|4f3j]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C1QTNF5, CTRP5, UNQ303/PRO344 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nn0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nn0 RCSB], [http://www.ebi.ac.uk/pdbsum/4nn0 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
[[http://www.uniprot.org/uniprot/C1QT5_HUMAN C1QT5_HUMAN]] Late-onset retinal degeneration. The disease is caused by mutations affecting the gene represented in this entry. | [[http://www.uniprot.org/uniprot/C1QT5_HUMAN C1QT5_HUMAN]] Late-onset retinal degeneration. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The C1q-tumor necrosis factor 5 (C1QTNF5) protein plays a significant role in retinal pigmented epithelium (RPE) cellular adhesion. The C1QTNF5 gene is co-transcribed with the frizzled-related protein (MFRP) gene. A Ser-to-Arg mutation at site 163 (S163R) in C1QTNF5 is known to cause late-onset retinal macular degeneration (L-ORMD). Here we also found that C1QTNF5 monomers can multimerize into a bouquet-like octadecamer. We found that a novel intermolecular hydrogen-bond network of S163 that glues adjacent globular heads of C1QTNF5 together was weakened or abolished by the R163 pathogenic mutation. These findings could underlie the structural basis of this protein's adhesive function and relate to the pathogenesis of its S163R mutation. Additionally, the fact that C1QTNF5 immobilized to a resin selectively enriched detergent extracted membrane-bound MFRP, further confirmed their interaction, implying functions other than cellular adhesion for C1QTNF5. | ||
| - | + | The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements.,Tu X, Palczewski K J Struct Biol. 2014 Feb 12. pii: S1047-8477(14)00025-2. doi:, 10.1016/j.jsb.2014.02.001. PMID:24531000<ref>PMID:24531000</ref> | |
| - | + | ||
| - | == | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
| - | + | </div> | |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: Palczewski, K | + | [[Category: Palczewski, K]] |
| - | [[Category: Tu, X | + | [[Category: Tu, X]] |
[[Category: 10-strand jelly-roll fold]] | [[Category: 10-strand jelly-roll fold]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
Revision as of 21:16, 25 December 2014
Crystal structure of the C1QTNF5 globular domain in space group P63
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