2qxw

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2qxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QXW FirstGlance]. <br>
<table><tr><td colspan='2'>[[2qxw]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QXW FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LDT:IDD594'>LDT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=LDT:IDD594'>LDT</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1us0|1us0]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1us0|1us0]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qxw RCSB], [http://www.ebi.ac.uk/pdbsum/2qxw PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qxw RCSB], [http://www.ebi.ac.uk/pdbsum/2qxw PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Aldehyde reductase]]
[[Category: Aldehyde reductase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Afonine, P.]]
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[[Category: Afonine, P]]
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[[Category: Blakeley, M P.]]
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[[Category: Blakeley, M P]]
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[[Category: Cachau, R.]]
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[[Category: Cachau, R]]
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[[Category: Cousido-Siah, A.]]
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[[Category: Cousido-Siah, A]]
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[[Category: Ginell, S.]]
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[[Category: Ginell, S]]
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[[Category: Hazemann, I.]]
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[[Category: Hazemann, I]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak, A]]
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[[Category: Meilleur, F.]]
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[[Category: Meilleur, F]]
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[[Category: Mitschler, A.]]
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[[Category: Mitschler, A]]
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[[Category: Myles, D.]]
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[[Category: Myles, D]]
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[[Category: Podjarny, A.]]
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[[Category: Podjarny, A]]
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[[Category: Ruiz, F.]]
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[[Category: Ruiz, F]]
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[[Category: Ventura, O.]]
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[[Category: Ventura, O]]
[[Category: Cataract]]
[[Category: Cataract]]
[[Category: Idd594]]
[[Category: Idd594]]
[[Category: Nadp]]
[[Category: Nadp]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]

Revision as of 21:17, 25 December 2014

Perdeuterated alr2 in complex with idd594

2qxw, resolution 0.80Å

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