3uuo

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3uuo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UUO FirstGlance]. <br>
<table><tr><td colspan='2'>[[3uuo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UUO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0CV:6-METHOXY-3,8-DIMETHYL-4-(PIPERAZIN-1-YL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>0CV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=0CV:6-METHOXY-3,8-DIMETHYL-4-(PIPERAZIN-1-YL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>0CV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uuo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uuo RCSB], [http://www.ebi.ac.uk/pdbsum/3uuo PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uuo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uuo RCSB], [http://www.ebi.ac.uk/pdbsum/3uuo PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.,Ho GD, Yang SW, Smotryski J, Bercovici A, Nechuta T, Smith EM, McElroy W, Tan Z, Tulshian D, McKittrick B, Greenlee WJ, Hruza A, Xiao L, Rindgen D, Mullins D, Guzzi M, Zhang X, Bleickardt C, Hodgson R Bioorg Med Chem Lett. 2012 Jan 15;22(2):1019-22. Epub 2011 Dec 9. PMID:22222034<ref>PMID:22222034</ref>
The discovery of potent, selective, and orally active pyrazoloquinolines as PDE10A inhibitors for the treatment of Schizophrenia.,Ho GD, Yang SW, Smotryski J, Bercovici A, Nechuta T, Smith EM, McElroy W, Tan Z, Tulshian D, McKittrick B, Greenlee WJ, Hruza A, Xiao L, Rindgen D, Mullins D, Guzzi M, Zhang X, Bleickardt C, Hodgson R Bioorg Med Chem Lett. 2012 Jan 15;22(2):1019-22. Epub 2011 Dec 9. PMID:22222034<ref>PMID:22222034</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bercovici, A.]]
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[[Category: Bercovici, A]]
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[[Category: Bleickardt, C.]]
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[[Category: Bleickardt, C]]
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[[Category: Greenlee, W J.]]
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[[Category: Greenlee, W J]]
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[[Category: Guzzi, M.]]
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[[Category: Guzzi, M]]
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[[Category: Ho, G D.]]
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[[Category: Ho, G D]]
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[[Category: Hodgson, R.]]
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[[Category: Hodgson, R]]
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[[Category: Hruza, A.]]
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[[Category: Hruza, A]]
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[[Category: McElroy, W.]]
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[[Category: McElroy, W]]
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[[Category: Mckittrick, B.]]
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[[Category: Mckittrick, B]]
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[[Category: Mullins, D.]]
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[[Category: Mullins, D]]
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[[Category: Nechuta, T.]]
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[[Category: Nechuta, T]]
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[[Category: Rindgen, D.]]
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[[Category: Rindgen, D]]
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[[Category: Smith, E M.]]
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[[Category: Smith, E M]]
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[[Category: Smotryski, J.]]
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[[Category: Smotryski, J]]
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[[Category: Tan, Z.]]
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[[Category: Tan, Z]]
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[[Category: Tulshian, D.]]
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[[Category: Tulshian, D]]
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[[Category: Xiao, L.]]
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[[Category: Xiao, L]]
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[[Category: Yang, S.]]
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[[Category: Yang, S]]
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[[Category: Zhang, X.]]
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[[Category: Zhang, X]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 21:17, 25 December 2014

The discovery of potent, selectivity, and orally bioavailable pyrozoloquinolines as PDE10 inhibitors for the treatment of Schizophrenia

3uuo, resolution 2.11Å

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