2ljb
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ljb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/taiwan/70061/2006) Influenza b virus (b/taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJB FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ljb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_b_virus_(b/taiwan/70061/2006) Influenza b virus (b/taiwan/70061/2006)]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LJB FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rlf|2rlf]], [[2kix|2kix]], [[2kih|2kih]], [[2kwx|2kwx]], [[2ljc|2ljc]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rlf|2rlf]], [[2kix|2kix]], [[2kih|2kih]], [[2kwx|2kwx]], [[2ljc|2ljc]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=529646 Influenza B virus (B/Taiwan/70061/2006)])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BM2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=529646 Influenza B virus (B/Taiwan/70061/2006)])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljb RCSB], [http://www.ebi.ac.uk/pdbsum/2ljb PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ljb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ljb RCSB], [http://www.ebi.ac.uk/pdbsum/2ljb PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q9YP62_9INFA Q9YP62_9INFA]] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation (By similarity).[SAAS:SAAS002089_004_400258] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Chou, J J | + | [[Category: Chou, J J]] |
| - | [[Category: Oxenoid, K | + | [[Category: Oxenoid, K]] |
| - | [[Category: Pielak, R M | + | [[Category: Pielak, R M]] |
[[Category: M2 channel]] | [[Category: M2 channel]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 21:21, 25 December 2014
Structure of the influenza AM2-BM2 chimeric channel
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