4a5v

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[[Image:4a5v.png|left|200px]]
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==Solution structure ensemble of the two N-terminal apple domains (residues 58-231) of Toxoplasma gondii microneme protein 4==
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<StructureSection load='4a5v' size='340' side='right' caption='[[4a5v]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4a5v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A5V FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a5v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a5v RCSB], [http://www.ebi.ac.uk/pdbsum/4a5v PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MIC4_TOXGO MIC4_TOXGO]] Adhesin. Required for attachment of the parasite to the host cell prior to invasion.<ref>PMID:11053441</ref> <ref>PMID:11157983</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Toxosplasma gondii is the model parasite of the phylum Apicomplexa, which contains numerous obligate intracellular parasites of medical and veterinary importance, including Eimeria, Sarcocystis, Cryptosporidium, Cyclospora and Plasmodium species. Members of this phylum actively enter host cells by a multi-step process with the help of microneme protein (MIC) complexes that play important roles in motility, host cell attachment, moving junction formation and invasion. Toxoplasma gondii (Tg)MIC1-4-6 complex is the most extensively investigated microneme complex which contributes to host cell recognition and attachment via the action of TgMIC1, a sialic acid-binding adhesin. Here, we report the structure of TgMIC4 and reveal its carbohydrate-binding specificity to a variety of galactose-containing carbohydrate ligands. The lectin is composed of six apple domains in which the fifth domain displays a potent galactose-binding activity, and which is cleaved from the complex during parasite invasion. We propose that galactose recognition by TgMIC4 masks the recognition of the parasite thereby providing protection from galectin-mediated activation of the host immune system.
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Galactose recognition by the apicomplexan parasite Toxoplasma gondii.,Marchant J, Cowper B, Liu Y, Lai L, Pinzan C, Marq JB, Friedrich N, Sawmynaden K, Liew L, Chai W, Childs RA, Saouros S, Simpson P, Roque Barreira MC, Feizi T, Soldati-Favre D, Matthews S J Biol Chem. 2012 Mar 7. PMID:22399295<ref>PMID:22399295</ref>
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The line below this paragraph, containing "STRUCTURE_4a5v", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_4a5v| PDB=4a5v | SCENE= }}
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===Solution structure ensemble of the two N-terminal apple domains (residues 58-231) of Toxoplasma gondii microneme protein 4===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22399295}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22399295 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22399295}}
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==About this Structure==
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[[4a5v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A5V OCA].
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==Reference==
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<ref group="xtra">PMID:022399295</ref><references group="xtra"/>
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[[Category: Toxoplasma gondii]]
[[Category: Toxoplasma gondii]]
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[[Category: Barreira, M C.R.]]
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[[Category: Barreira, M C.R]]
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[[Category: Chai, W.]]
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[[Category: Chai, W]]
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[[Category: Childs, R A.]]
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[[Category: Childs, R A]]
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[[Category: Cowper, B.]]
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[[Category: Cowper, B]]
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[[Category: Feizi, T.]]
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[[Category: Feizi, T]]
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[[Category: Friedrich, N.]]
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[[Category: Friedrich, N]]
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[[Category: Lai, L.]]
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[[Category: Lai, L]]
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[[Category: Liu, Y.]]
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[[Category: Liu, Y]]
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[[Category: Marchant, J.]]
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[[Category: Marchant, J]]
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[[Category: Marq, J B.]]
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[[Category: Marq, J B]]
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[[Category: Matthews, S.]]
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[[Category: Matthews, S]]
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[[Category: Pinzan, C.]]
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[[Category: Pinzan, C]]
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[[Category: Saouros, S.]]
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[[Category: Saouros, S]]
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[[Category: Sawmynaden, K.]]
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[[Category: Sawmynaden, K]]
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[[Category: Simpson, P.]]
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[[Category: Simpson, P]]
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[[Category: Soldati-Favre, D.]]
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[[Category: Soldati-Favre, D]]
[[Category: Adhesion]]
[[Category: Adhesion]]

Revision as of 21:25, 25 December 2014

Solution structure ensemble of the two N-terminal apple domains (residues 58-231) of Toxoplasma gondii microneme protein 4

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