4ac3
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ac3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AC3 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ac3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AC3 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R83:N-{2,4-DIMETHOXY-5-[(2-PIPERIDIN-1-YLBENZYL)SULFAMOYL]PHENYL}ACETAMIDE'>R83</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R83:N-{2,4-DIMETHOXY-5-[(2-PIPERIDIN-1-YLBENZYL)SULFAMOYL]PHENYL}ACETAMIDE'>R83</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4aaw|4aaw]], [[4aa7|4aa7]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4aaw|4aaw]], [[4aa7|4aa7]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ac3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ac3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ac3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ac3 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ac3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ac3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ac3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ac3 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLMU_STRR6 GLMU_STRR6]] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Streptococcus pneumoniae]] | [[Category: Streptococcus pneumoniae]] | ||
| - | [[Category: Breed, J | + | [[Category: Breed, J]] |
| - | [[Category: Ogg, D J | + | [[Category: Ogg, D J]] |
| - | [[Category: Otterbein, L | + | [[Category: Otterbein, L]] |
[[Category: Acetyl transferase]] | [[Category: Acetyl transferase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Transferase-inhibitor complex]] | [[Category: Transferase-inhibitor complex]] | ||
Revision as of 21:37, 25 December 2014
S.pneumoniae GlmU in complex with an antibacterial inhibitor
| |||||||||||
