4cix
From Proteopedia
(Difference between revisions)
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<StructureSection load='4cix' size='340' side='right' caption='[[4cix]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='4cix' size='340' side='right' caption='[[4cix]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIX OCA]. <br> | + | <table><tr><td colspan='2'>[[4cix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CIX FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W4N:(1R,4R,5R)-1,4,5-TRIHYDROXY-3-[(1S)-1-HYDROXY-2-PHENYL]ETHYLCYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>W4N</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W4N:(1R,4R,5R)-1,4,5-TRIHYDROXY-3-[(1S)-1-HYDROXY-2-PHENYL]ETHYLCYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>W4N</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4civ|4civ]], [[4ciw|4ciw]], [[4ciy|4ciy]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4civ|4civ]], [[4ciw|4ciw]], [[4ciy|4ciy]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cix OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cix RCSB], [http://www.ebi.ac.uk/pdbsum/4cix PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cix OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cix RCSB], [http://www.ebi.ac.uk/pdbsum/4cix PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors.,Blanco B, Sedes A, Peon A, Otero JM, Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C J Med Chem. 2014 Apr 1. PMID:24689821<ref>PMID:24689821</ref> | Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors.,Blanco B, Sedes A, Peon A, Otero JM, Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C J Med Chem. 2014 Apr 1. PMID:24689821<ref>PMID:24689821</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: 3-dehydroquinate dehydratase]] | [[Category: 3-dehydroquinate dehydratase]] | ||
| - | [[Category: Blanco, B | + | [[Category: Blanco, B]] |
| - | [[Category: Gonzalez-Bello, C | + | [[Category: Gonzalez-Bello, C]] |
| - | [[Category: Hawkins, A R | + | [[Category: Hawkins, A R]] |
| - | [[Category: Lamb, H | + | [[Category: Lamb, H]] |
| - | [[Category: Llamas-Saiz, A L | + | [[Category: Llamas-Saiz, A L]] |
| - | [[Category: Otero, J M | + | [[Category: Otero, J M]] |
| - | [[Category: Peon, A | + | [[Category: Peon, A]] |
| - | [[Category: Raaij, M J.van | + | [[Category: Raaij, M J.van]] |
| - | [[Category: Sedes, A | + | [[Category: Sedes, A]] |
[[Category: Bacterial protein]] | [[Category: Bacterial protein]] | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
Revision as of 21:38, 25 December 2014
Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with(1R,4R,5R)-1,4,5-trihydroxy-3-((1S)-1-hydroxy-2-phenyl) ethylcyclohex-2-en-1-carboxylic acid
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