This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4cix
From Proteopedia
(Difference between revisions)
| Line 2: | Line 2: | ||
<StructureSection load='4cix' size='340' side='right' caption='[[4cix]], [[Resolution|resolution]] 2.90Å' scene=''> | <StructureSection load='4cix' size='340' side='right' caption='[[4cix]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIX OCA]. <br> | + | <table><tr><td colspan='2'>[[4cix]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CIX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CIX FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W4N:(1R,4R,5R)-1,4,5-TRIHYDROXY-3-[(1S)-1-HYDROXY-2-PHENYL]ETHYLCYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>W4N</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=W4N:(1R,4R,5R)-1,4,5-TRIHYDROXY-3-[(1S)-1-HYDROXY-2-PHENYL]ETHYLCYCLOHEX-2-ENE-1-CARBOXYLIC+ACID'>W4N</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4civ|4civ]], [[4ciw|4ciw]], [[4ciy|4ciy]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4civ|4civ]], [[4ciw|4ciw]], [[4ciy|4ciy]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/ | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-dehydroquinate_dehydratase 3-dehydroquinate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.10 4.2.1.10] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cix OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cix RCSB], [http://www.ebi.ac.uk/pdbsum/4cix PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cix OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cix RCSB], [http://www.ebi.ac.uk/pdbsum/4cix PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AROQ_MYCTU AROQ_MYCTU]] Catalyzes a trans-dehydration via an enolate intermediate (By similarity).[HAMAP-Rule:MF_00169] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 14: | Line 16: | ||
Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors.,Blanco B, Sedes A, Peon A, Otero JM, Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C J Med Chem. 2014 Apr 1. PMID:24689821<ref>PMID:24689821</ref> | Exploring the Water-Binding Pocket of the Type II Dehydroquinase Enzyme in the Structure-Based Design of Inhibitors.,Blanco B, Sedes A, Peon A, Otero JM, Raaij MJ, Thompson P, Hawkins AR, Gonzalez-Bello C J Med Chem. 2014 Apr 1. PMID:24689821<ref>PMID:24689821</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
| Line 21: | Line 23: | ||
</StructureSection> | </StructureSection> | ||
[[Category: 3-dehydroquinate dehydratase]] | [[Category: 3-dehydroquinate dehydratase]] | ||
| - | [[Category: Blanco, B | + | [[Category: Blanco, B]] |
| - | [[Category: Gonzalez-Bello, C | + | [[Category: Gonzalez-Bello, C]] |
| - | [[Category: Hawkins, A R | + | [[Category: Hawkins, A R]] |
| - | [[Category: Lamb, H | + | [[Category: Lamb, H]] |
| - | [[Category: Llamas-Saiz, A L | + | [[Category: Llamas-Saiz, A L]] |
| - | [[Category: Otero, J M | + | [[Category: Otero, J M]] |
| - | [[Category: Peon, A | + | [[Category: Peon, A]] |
| - | [[Category: Raaij, M J.van | + | [[Category: Raaij, M J.van]] |
| - | [[Category: Sedes, A | + | [[Category: Sedes, A]] |
[[Category: Bacterial protein]] | [[Category: Bacterial protein]] | ||
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
Revision as of 21:38, 25 December 2014
Crystal structure of Mycobacterium tuberculosis type 2 dehydroquinase in complex with(1R,4R,5R)-1,4,5-trihydroxy-3-((1S)-1-hydroxy-2-phenyl) ethylcyclohex-2-en-1-carboxylic acid
| |||||||||||
