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2hgs
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2hgs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HGS FirstGlance]. <br> | <table><tr><td colspan='2'>[[2hgs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HGS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2HGS FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_synthase Glutathione synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.3 6.3.2.3] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hgs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hgs RCSB], [http://www.ebi.ac.uk/pdbsum/2hgs PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hgs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2hgs RCSB], [http://www.ebi.ac.uk/pdbsum/2hgs PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/GSHB_HUMAN GSHB_HUMAN]] Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency) [MIM:[http://omim.org/entry/266130 266130]]; also known as 5-oxoprolinuria or pyroglutamic aciduria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. Defects in GSS are the cause of glutathione synthetase deficiency of erythrocytes (GLUSYNDE)[MIM:[http://omim.org/entry/231900 231900]]. Glutathione synthetase deficiency of erythrocytes is a mild form causing hemolytic anemia. | [[http://www.uniprot.org/uniprot/GSHB_HUMAN GSHB_HUMAN]] Defects in GSS are the cause of glutathione synthetase deficiency (GSS deficiency) [MIM:[http://omim.org/entry/266130 266130]]; also known as 5-oxoprolinuria or pyroglutamic aciduria. It is a severe form characterized by an increased rate of hemolysis and defective function of the central nervous system. Defects in GSS are the cause of glutathione synthetase deficiency of erythrocytes (GLUSYNDE)[MIM:[http://omim.org/entry/231900 231900]]. Glutathione synthetase deficiency of erythrocytes is a mild form causing hemolytic anemia. | ||
| - | == Function == | ||
| - | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Glutathione synthetase|Glutathione synthetase]] | *[[Glutathione synthetase|Glutathione synthetase]] | ||
| + | *[[TolB|TolB]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
| Line 38: | Line 37: | ||
[[Category: Glutathione synthase]] | [[Category: Glutathione synthase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Board, P | + | [[Category: Board, P]] |
| - | [[Category: Parker, M W | + | [[Category: Parker, M W]] |
| - | [[Category: Polekhina, G | + | [[Category: Polekhina, G]] |
| - | [[Category: Rossjohn, J | + | [[Category: Rossjohn, J]] |
[[Category: Amine-carboxylate ligase complex]] | [[Category: Amine-carboxylate ligase complex]] | ||
[[Category: Amine/carboxylate ligase]] | [[Category: Amine/carboxylate ligase]] | ||
Revision as of 21:40, 25 December 2014
HUMAN GLUTATHIONE SYNTHETASE
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