2gg1
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2gg1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Langat_virus Langat virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yzo 1yzo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GG1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2gg1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Langat_virus Langat virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1yzo 1yzo]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GG1 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z66|1z66]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1z66|1z66]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gg1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gg1 RCSB], [http://www.ebi.ac.uk/pdbsum/2gg1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gg1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gg1 RCSB], [http://www.ebi.ac.uk/pdbsum/2gg1 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/POLG_LANVY POLG_LANVY]] Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA (By similarity). prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity). Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Langat virus]] | [[Category: Langat virus]] | ||
| - | [[Category: Cowburn, D | + | [[Category: Cowburn, D]] |
| - | [[Category: Dutta, K | + | [[Category: Dutta, K]] |
| - | [[Category: Fox, R O | + | [[Category: Fox, R O]] |
| - | [[Category: Mukherjee, M | + | [[Category: Mukherjee, M]] |
| - | [[Category: White, M A | + | [[Category: White, M A]] |
[[Category: Domain iii]] | [[Category: Domain iii]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||
Revision as of 21:40, 25 December 2014
NMR solution structure of domain III of the E-protein of tick-borne Langat flavivirus (includes RDC restraints)
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