3h9f

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3h9f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H9F FirstGlance]. <br>
<table><tr><td colspan='2'>[[3h9f]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H9F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3H9F FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=92M:9-CYCLOPENTYL-2-(4-(4-HYDROXYPIPERIDIN-1-YL)-2-METHOXYPHENYLAMINO)-5-METHYL-8,9-DIHYDRO-5H-PYRIMIDO[4,5-B][1,4]DIAZEPIN-6(7H)-ONE'>92M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=92M:9-CYCLOPENTYL-2-(4-(4-HYDROXYPIPERIDIN-1-YL)-2-METHOXYPHENYLAMINO)-5-METHYL-8,9-DIHYDRO-5H-PYRIMIDO[4,5-B][1,4]DIAZEPIN-6(7H)-ONE'>92M</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPS1L1, TTK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPS1L1, TTK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h9f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h9f RCSB], [http://www.ebi.ac.uk/pdbsum/3h9f PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3h9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h9f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3h9f RCSB], [http://www.ebi.ac.uk/pdbsum/3h9f PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Dual-specificity kinase]]
[[Category: Dual-specificity kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C.]]
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[[Category: Bountra, C]]
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[[Category: Chaikuad, A.]]
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[[Category: Chaikuad, A]]
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[[Category: Delft, F von.]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A.]]
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[[Category: Edwards, A]]
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[[Category: Elkins, J M.]]
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[[Category: Elkins, J M]]
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[[Category: Fedorov, O.]]
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[[Category: Fedorov, O]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Filippakopoulos, P]]
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[[Category: Gray, N S.]]
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[[Category: Gray, N S]]
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[[Category: Keates, T.]]
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[[Category: Keates, T]]
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[[Category: King, O.]]
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[[Category: King, O]]
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[[Category: Knapp, S.]]
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[[Category: Knapp, S]]
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[[Category: Kwiatkowski, N.]]
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[[Category: Kwiatkowski, N]]
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[[Category: Picaud, S S.]]
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[[Category: Picaud, S S]]
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[[Category: Pike, A C.W.]]
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[[Category: Pike, A C.W]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Structural genomic]]
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[[Category: Soundararajan, M.]]
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[[Category: Soundararajan, M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt, J]]
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[[Category: Yue, W.]]
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[[Category: Yue, W]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Dual specificity]]
[[Category: Dual specificity]]
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Sgc]]
[[Category: Sgc]]
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[[Category: Structural genomics consortium]]
 
[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Ttk]]
[[Category: Ttk]]
[[Category: Tyrosine-protein kinase]]
[[Category: Tyrosine-protein kinase]]

Revision as of 21:43, 25 December 2014

Crystal Structure of Human Dual Specificity Protein Kinase (TTK) in complex with a pyrimido-diazepin ligand

3h9f, resolution 2.60Å

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OCA

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