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1m2c
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1m2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M2C FirstGlance]. <br> | <table><tr><td colspan='2'>[[1m2c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M2C FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m2c RCSB], [http://www.ebi.ac.uk/pdbsum/1m2c PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m2c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1m2c RCSB], [http://www.ebi.ac.uk/pdbsum/1m2c PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CXA2_CONMA CXA2_CONMA]] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin blocks neuronal mammalian nAChRs (alpha-6 or -3/beta-2 or -3 > alpha-3/beta-2 > alpha-3/beta-4 = alpha-4/beta-2).<ref>PMID:8631783</ref> <ref>PMID:11044728</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Conus magus]] | [[Category: Conus magus]] | ||
| - | [[Category: Koerber, S C | + | [[Category: Koerber, S C]] |
| - | [[Category: Mcintosh, J M | + | [[Category: Mcintosh, J M]] |
| - | [[Category: Olivera, B M | + | [[Category: Olivera, B M]] |
| - | [[Category: Rivier, J E | + | [[Category: Rivier, J E]] |
| - | [[Category: Shon, K J | + | [[Category: Shon, K J]] |
[[Category: Cholinergic modulation]] | [[Category: Cholinergic modulation]] | ||
[[Category: Dopamine release]] | [[Category: Dopamine release]] | ||
Revision as of 21:52, 25 December 2014
THREE-DIMENSIONAL STRUCTURE OF ALPHA-CONOTOXIN MII, NMR, 14 STRUCTURES
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