4lg9
From Proteopedia
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| - | + | ==Crystal structure of TBL1XR1 WD40 repeats== | |
| - | === | + | <StructureSection load='4lg9' size='340' side='right' caption='[[4lg9]], [[Resolution|resolution]] 2.28Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4lg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LG9 FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TBL1XR1, IRA1, TBLR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lg9 RCSB], [http://www.ebi.ac.uk/pdbsum/4lg9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/TBL1R_HUMAN TBL1R_HUMAN]] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.<ref>PMID:14980219</ref> | [[http://www.uniprot.org/uniprot/TBL1R_HUMAN TBL1R_HUMAN]] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.<ref>PMID:14980219</ref> | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Human]] | |
| - | <references | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Bountra, C]] |
| - | [[Category: Bountra, C | + | [[Category: Edwards, A M]] |
| - | [[Category: Edwards, A M | + | [[Category: He, H]] |
| - | [[Category: He, H | + | [[Category: Min, J]] |
| - | [[Category: Min, J | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Tempel, W]] |
| - | [[Category: Tempel, W | + | [[Category: Wu, X]] |
| - | [[Category: Wu, X | + | [[Category: Xu, C]] |
| - | [[Category: Xu, C | + | |
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
[[Category: Wd40 repeat]] | [[Category: Wd40 repeat]] | ||
Revision as of 21:55, 25 December 2014
Crystal structure of TBL1XR1 WD40 repeats
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Categories: Human | Arrowsmith, C H | Bountra, C | Edwards, A M | He, H | Min, J | Structural genomic | Tempel, W | Wu, X | Xu, C | Sgc | Unknown function | Wd40 repeat
