This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4lg9
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | + | ==Crystal structure of TBL1XR1 WD40 repeats== | |
| - | === | + | <StructureSection load='4lg9' size='340' side='right' caption='[[4lg9]], [[Resolution|resolution]] 2.28Å' scene=''> |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[4lg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LG9 FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TBL1XR1, IRA1, TBLR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lg9 RCSB], [http://www.ebi.ac.uk/pdbsum/4lg9 PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/TBL1R_HUMAN TBL1R_HUMAN]] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.<ref>PMID:14980219</ref> | [[http://www.uniprot.org/uniprot/TBL1R_HUMAN TBL1R_HUMAN]] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.<ref>PMID:14980219</ref> | ||
| - | + | == References == | |
| - | == | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Human]] | |
| - | <references | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Bountra, C]] |
| - | [[Category: Bountra, C | + | [[Category: Edwards, A M]] |
| - | [[Category: Edwards, A M | + | [[Category: He, H]] |
| - | [[Category: He, H | + | [[Category: Min, J]] |
| - | [[Category: Min, J | + | [[Category: Structural genomic]] |
| - | [[Category: | + | [[Category: Tempel, W]] |
| - | [[Category: Tempel, W | + | [[Category: Wu, X]] |
| - | [[Category: Wu, X | + | [[Category: Xu, C]] |
| - | [[Category: Xu, C | + | |
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
[[Category: Wd40 repeat]] | [[Category: Wd40 repeat]] | ||
Revision as of 21:55, 25 December 2014
Crystal structure of TBL1XR1 WD40 repeats
| |||||||||||
Categories: Human | Arrowsmith, C H | Bountra, C | Edwards, A M | He, H | Min, J | Structural genomic | Tempel, W | Wu, X | Xu, C | Sgc | Unknown function | Wd40 repeat
