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3gg6
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gg6 RCSB], [http://www.ebi.ac.uk/pdbsum/3gg6 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3gg6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gg6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3gg6 RCSB], [http://www.ebi.ac.uk/pdbsum/3gg6 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NUD18_HUMAN NUD18_HUMAN]] Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 21:59, 25 December 2014
Crystal structure of the NUDIX domain of human NUDT18
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Categories: Homo sapiens | Arrowsmith, C H | Berg, S Van Den | Berglund, H | Bountra, C | Collins, R | Dahlgren, L G | Edwards, A M | Flodin, S | Flores, A | Graslund, S | Hammarstrom, M | Johansson, A | Johansson, I | Karlberg, T | Kotenyova, T | Lehtio, L | Moche, M | Nilsson, M E | Nordlund, P | Nyman, T | Persson, C | Structural genomic | Sagemark, J | Schueler, H | Siponen, M I | Thorsell, A G | Tresaugues, L | Weigelt, J | Welin, M | Wisniewska, M | Hydrolase | Magnesium | Manganese | Metal-binding | Nucleotide hydrolase | Nudix | Nudt18 | Nxr1 | Sgc | Sgc stockholm
