1o5f
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1o5f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5F FirstGlance]. <br> | <table><tr><td colspan='2'>[[1o5f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1O5F FirstGlance]. <br> | ||
- | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CR9:2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE'>CR9</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CR9:2-{5-[AMINO(IMINIO)METHYL]-6-FLUORO-1H-BENZIMIDAZOL-2-YL}-6-[(2-METHYLCYCLOHEXYL)OXY]BENZENOLATE'>CR9</scene></td></tr> |
- | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p57|1p57]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p57|1p57]]</td></tr> |
- | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HPN OR TMPRSS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
- | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o5f RCSB], [http://www.ebi.ac.uk/pdbsum/1o5f PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o5f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1o5f RCSB], [http://www.ebi.ac.uk/pdbsum/1o5f PDBsum]</span></td></tr> |
- | <table> | + | </table> |
+ | == Function == | ||
+ | [[http://www.uniprot.org/uniprot/HEPS_HUMAN HEPS_HUMAN]] Plays an essential role in cell growth and maintenance of cell morphology. May mediate the activating cleavage of HGF and MST1/HGFL.<ref>PMID:21875933</ref> <ref>PMID:15839837</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
- | [[Category: Chan, H | + | [[Category: Chan, H]] |
- | [[Category: Gjerstad, E | + | [[Category: Gjerstad, E]] |
- | [[Category: Ho, J D | + | [[Category: Ho, J D]] |
- | [[Category: Janc, J W | + | [[Category: Janc, J W]] |
- | [[Category: Katz, B A | + | [[Category: Katz, B A]] |
- | [[Category: Luong, C | + | [[Category: Luong, C]] |
- | [[Category: Mackman, R L | + | [[Category: Mackman, R L]] |
- | [[Category: McGrath, M E | + | [[Category: McGrath, M E]] |
- | [[Category: Mortara, K | + | [[Category: Mortara, K]] |
- | [[Category: Somoza, J R | + | [[Category: Somoza, J R]] |
- | [[Category: Sprengeler, P A | + | [[Category: Sprengeler, P A]] |
- | [[Category: Tang, J | + | [[Category: Tang, J]] |
- | [[Category: Verner, E | + | [[Category: Verner, E]] |
- | [[Category: Williams, S R | + | [[Category: Williams, S R]] |
- | [[Category: Young, W B | + | [[Category: Young, W B]] |
[[Category: Conserved water displacement hydrogen bond deficit]] | [[Category: Conserved water displacement hydrogen bond deficit]] | ||
[[Category: Factor viia]] | [[Category: Factor viia]] |
Revision as of 22:04, 25 December 2014
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)
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Categories: Homo sapiens | Chan, H | Gjerstad, E | Ho, J D | Janc, J W | Katz, B A | Luong, C | Mackman, R L | McGrath, M E | Mortara, K | Somoza, J R | Sprengeler, P A | Tang, J | Verner, E | Williams, S R | Young, W B | Conserved water displacement hydrogen bond deficit | Factor viia | Hepsin | Hydrolase | S1 site | Scavenger receptor cysteine-rich domain | Selectivity | Serine protease | Serine protease ala190 upa | Srcr | Thrombin | Trypsin