2fk0
From Proteopedia
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| - | [[Image:2fk0.gif|left|200px]] | + | [[Image:2fk0.gif|left|200px]] |
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| - | '''Crystal Structure of a H5N1 influenza virus hemagglutinin.''' | + | {{Structure |
| + | |PDB= 2fk0 |SIZE=350|CAPTION= <scene name='initialview01'>2fk0</scene>, resolution 2.95Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Crystal Structure of a H5N1 influenza virus hemagglutinin.''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2FK0 is a [ | + | 2FK0 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/viet_nam/1203/2004(h5n1)) Influenza a virus (a/viet nam/1203/2004(h5n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FK0 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus., Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA, Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. PMID:[http:// | + | Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus., Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA, Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16543414 16543414] |
[[Category: Influenza a virus (a/viet nam/1203/2004(h5n1))]] | [[Category: Influenza a virus (a/viet nam/1203/2004(h5n1))]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
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[[Category: virus/viral protein]] | [[Category: virus/viral protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:53:21 2008'' |
Revision as of 14:53, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of a H5N1 influenza virus hemagglutinin.
Overview
The hemagglutinin (HA) structure at 2.9 angstrom resolution, from a highly pathogenic Vietnamese H5N1 influenza virus, is more related to the 1918 and other human H1 HAs than to a 1997 duck H5 HA. Glycan microarray analysis of this Viet04 HA reveals an avian alpha2-3 sialic acid receptor binding preference. Introduction of mutations that can convert H1 serotype HAs to human alpha2-6 receptor specificity only enhanced or reduced affinity for avian-type receptors. However, mutations that can convert avian H2 and H3 HAs to human receptor specificity, when inserted onto the Viet04 H5 HA framework, permitted binding to a natural human alpha2-6 glycan, which suggests a path for this H5N1 virus to gain a foothold in the human population.
About this Structure
2FK0 is a Protein complex structure of sequences from Influenza a virus (a/viet nam/1203/2004(h5n1)). Full crystallographic information is available from OCA.
Reference
Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus., Stevens J, Blixt O, Tumpey TM, Taubenberger JK, Paulson JC, Wilson IA, Science. 2006 Apr 21;312(5772):404-10. Epub 2006 Mar 16. PMID:16543414
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