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4h5b
From Proteopedia
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| - | + | ==Crystal Structure of DR_1245 from Deinococcus radiodurans== | |
| - | === | + | <StructureSection load='4h5b' size='340' side='right' caption='[[4h5b]], [[Resolution|resolution]] 2.00Å' scene=''> |
| - | + | == Structural highlights == | |
| + | <table><tr><td colspan='2'>[[4h5b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H5B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H5B FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DR_1245 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243230 Deinococcus radiodurans R1])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h5b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4h5b RCSB], [http://www.ebi.ac.uk/pdbsum/4h5b PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The bacterium Deinococcus radiodurans exhibits an extreme resistance to ionizing radiation. A small subset of Deinococcus genus-specific genes were shown to be up-regulated upon exposure to ionizing radiation and to play a role in genome reconstitution. These genes include an SSB-like protein called DdrB. Here, we identified a novel protein encoded by the dr1245 gene as an interacting partner of DdrB. A strain devoid of the DR1245 protein is impaired in growth, exhibiting a generation time approximately threefold that of the wild type strain while radioresistance is not affected. We determined the three-dimensional structure of DR1245, revealing a relationship with type III secretion system chaperones and YbjN family proteins. Thus, DR1245 may display some chaperone activity towards DdrB and possibly other substrates. | ||
| - | + | The Deinococcus radiodurans DR1245 Protein, a DdrB Partner Homologous to YbjN Proteins and Reminiscent of Type III Secretion System Chaperones.,Norais C, Servant P, Bouthier-de-la-Tour C, Coureux PD, Ithurbide S, Vannier F, Guerin PP, Dulberger CL, Satyshur KA, Keck JL, Armengaud J, Cox MM, Sommer S PLoS One. 2013;8(2):e56558. doi: 10.1371/journal.pone.0056558. Epub 2013 Feb 18. PMID:23441204<ref>PMID:23441204</ref> | |
| - | + | ||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Deinococcus radiodurans r1]] | [[Category: Deinococcus radiodurans r1]] | ||
| - | [[Category: Armengaud, J | + | [[Category: Armengaud, J]] |
| - | [[Category: Bouthier-de-la-Tour, C | + | [[Category: Bouthier-de-la-Tour, C]] |
| - | [[Category: Coureux, P D | + | [[Category: Coureux, P D]] |
| - | [[Category: Cox, M M | + | [[Category: Cox, M M]] |
| - | [[Category: Dulberger, C L | + | [[Category: Dulberger, C L]] |
| - | [[Category: Guerin, P | + | [[Category: Guerin, P]] |
| - | [[Category: Ithurbide, S | + | [[Category: Ithurbide, S]] |
| - | [[Category: Keck, J L | + | [[Category: Keck, J L]] |
| - | [[Category: Norais, C | + | [[Category: Norais, C]] |
| - | [[Category: Satyshur, K A | + | [[Category: Satyshur, K A]] |
| - | [[Category: Servant, P | + | [[Category: Servant, P]] |
| - | [[Category: Sommer, S | + | [[Category: Sommer, S]] |
| - | [[Category: Vannier, F | + | [[Category: Vannier, F]] |
[[Category: Secretion chaperone-like fold]] | [[Category: Secretion chaperone-like fold]] | ||
[[Category: Unknown function]] | [[Category: Unknown function]] | ||
Revision as of 22:09, 25 December 2014
Crystal Structure of DR_1245 from Deinococcus radiodurans
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