2c7a

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2c7a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C7A FirstGlance]. <br>
<table><tr><td colspan='2'>[[2c7a]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C7A FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a28|1a28]], [[1e3k|1e3k]], [[1sqn|1sqn]], [[1sr7|1sr7]], [[1zuc|1zuc]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1a28|1a28]], [[1e3k|1e3k]], [[1sqn|1sqn]], [[1sr7|1sr7]], [[1zuc|1zuc]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c7a RCSB], [http://www.ebi.ac.uk/pdbsum/2c7a PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2c7a RCSB], [http://www.ebi.ac.uk/pdbsum/2c7a PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN]] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Churchill, M E.A.]]
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[[Category: Churchill, M E.A]]
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[[Category: Donham, D C.]]
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[[Category: Donham, D C]]
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[[Category: Edwards, D P.]]
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[[Category: Edwards, D P]]
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[[Category: Pon, V H.]]
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[[Category: Pon, V H]]
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[[Category: Roemer, S C.]]
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[[Category: Roemer, S C]]
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[[Category: Sherman, L.]]
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[[Category: Sherman, L]]
[[Category: Complex]]
[[Category: Complex]]
[[Category: Dna-binding]]
[[Category: Dna-binding]]

Revision as of 22:09, 25 December 2014

STRUCTURE OF THE PROGESTERONE RECEPTOR-DNA COMPLEX

2c7a, resolution 2.50Å

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